Overexpression of Acid Ceramidase Protects from Tumor Necrosis Factor–Induced Cell Death
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منابع مشابه
Overexpression of Acid Ceramidase Protects from Tumor Necrosis Factor–Induced Cell Death
Tumor necrosis factor (TNF) signals cell death and simultaneously induces generation of ceramide. To evaluate the contribution of ceramide to TNF-dependent cell death, we generated clones of the TNF-sensitive cell line L929 that constitutively overexpress human acid ceramidase (AC). Ceramidase, in concert with sphingosine kinase, metabolizes ceramide to sphingosine-1-phosphate (SPP), an inducer...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2000
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.192.5.601